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KMID : 1140120080130020091
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Cancer Prevention Research
2008 Volume.13 No. 2 p.91 ~ p.95
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Genetic Difference of Angiotensin Converting Enzyme (I/D) Polymorphism in Korean Lung Cancer and Schizophrenia Patients
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Yun Jee-Yeong
Kim Yong-Ho
Kim Bum-Shik
Kim Keon-Sik
Chung Joo-Ho
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Abstract
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The reduced incidence of cancer observed in schizophrenia patients is one of interesting medical puzzles in research field of cancer development over decades. It has been reported that genetic factor towards schizophrenia is associated with reduced vulnerability to lung cancer. Genetic difference between lung cancer and schizophrenia might provide us with possible clues to understand molecular mechanisms of the pathophysiology of cancer or schizophrenia. We tested the genetic association between lung cancer and schizophrenia by analyzing well-known in/del (I/D) polymorphic site in the angiotensin converting enzyme (ACE) gene. ACE I/D polymorphism was studied in 94 lung cancer, 89 schizophrenia, and 1,267 healthy controls in Korean population. Genotype and allele frequencies of ACE I/D polymorphism showed significant differences between lung cancer and schizophrenia [genotype, p=0.0252; allele, p=0.0325; odds ratio (OR)=0.6341; 95% confidence interval (CI)=0.4173?0.9636]. Compared with controls, schizophrenia showed no significant differences in genotype and allele frequencies (genotype, p=0.2382; allele, p=0.5882; OR=1.0877; 95% CI=0.8022?1.4747). Lung cancer showed significant differences in genotype and allele frequencies (genotype, p=0.0017; allele, p=0.0005; OR=1.7153; 95% CI=1.2612?2.3328). The results suggest that ACE I/D polymorphism may be associated with the development of lung cancer, and may, in part, be explained a medical puzzle about low incidence of lung cancer in schizophrenia patients. (Cancer Prev Res 13, 91-95, 2008)
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KEYWORD
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Association, Angiotensin converting enzyme, Lung cancer, Polymorphism, Schizophrenia
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